Tonight, Supergirl returns from its holiday hiatus. When we last left off, CADMUS had unleashed its deadly Project Medusa virus, which had originally been created by Kara’s father as a precautionary weapon to kill all non-Kryptonians but has now been altered to eliminate all non-humans. A small-scale test of the weapon left Mon-El infected and Eliza looking for a cure. Supergirl tried to stop Lillian from dispersing more of the virus, but she arrived too late – Lena had already launched the rocket. However, it turned out that Lena was only pretending to help her mother and that she had replaced the virus with an inert gas. Elsewhere, J’onn was locked in a battle with Cyborg Superman and was forced to use his White Martian mutation to defeat him. At the end of the episode, Alex finally got a chance to come out to her sister, just before Kara was whisked off by Barry Allen and Cisco for her big DC crossover adventure…

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